When Does Alex Leave Grey's Anatomy? Key Episode Explained - thedigitalweekly.com

By Drift Striker · February 19, 2026

Alex Karev leaves Grey’s Anatomy in Season 16’s episode “Leave a Light On”, which aired on March 5, 2020. That’s when the show officially closes his story, revealing via voice-over letters that he’s moved to Kansas to be with Izzie and their children. The Exit in Context: When and Why Alex’s last physical appearance occurs […]